CVE-2022-46280
Duplicate Advisory: Open Babel has uninitialized pointer dereference in PQS pFormat
A use of uninitialized pointer vulnerability exists in the PQS format pFormat functionality of Open Babel 3.1.1 and master commit 530dbfa3. A specially crafted malformed file can lead to arbitrary code execution. An attacker can provide a malicious file to trigger this vulnerability.
Attack profile
How easy it is to exploit
- Attack vector
- Network
- Complexity
- Low
- Privileges needed
- None
- User interaction
- None
What an attacker can affect
- Confidentiality
- High
- Integrity
- High
- Availability
- High
Exploit likelihood
What each source reports
CVE List Score used
9.8
A use of uninitialized pointer vulnerability exists in the PQS format pFormat functionality of Open Babel 3.1.1 and master commit 530dbfa3. A specially crafted malformed file can lead to arbitrary code execution. An attacker can provide a malicious file to trigger this vulnerability.
- Record
CVE-2022-46280- CVSS 3.1
- 9.8 Critical
CVSS:3.1/AV:N/AC:L/PR:N/UI:N/S:U/C:H/I:H/A:H - Weakness
- CWE-824
- Updated
- 2026-11-02
EUVDEUVD-2022-49099
9.8
Open Babel has uninitialized pointer dereference in PQS pFormat
- Record
EUVD-2022-49099- CVSS 3.1
- 9.8 Critical
CVSS:3.1/AV:N/AC:L/PR:N/UI:N/S:U/C:H/I:H/A:H - Updated
- 2026-11-02
GitHub AdvisoriesGHSA-7rcm-w6ff-j43w
9.8
Duplicate Advisory: Open Babel has uninitialized pointer dereference in PQS pFormat
Duplicate Advisory
This advisory has been withdrawn because it is a duplicate of GHSA-8qxc-57hf-hc9j. This link is maintained to preserve external references.
Original Description
A use of uninitialized pointer vulnerability exists in the PQS format pFormat functionality of Open Babel 3.1.1 and master commit 530dbfa3. A specially crafted malformed file can lead to arbitrary code execution. An attacker can provide a malicious file to trigger this vulnerability.
- Record
GHSA-7rcm-w6ff-j43w- CVSS 3.1
- 9.8 Critical
CVSS:3.1/AV:N/AC:L/PR:N/UI:N/S:U/C:H/I:H/A:H - Weakness
- CWE-824
- Updated
- 2026-11-02
GitHub AdvisoriesGHSA-8qxc-57hf-hc9j
7.8
Open Babel has uninitialized pointer dereference in PQS pFormat
Summary
A memory-safety vulnerability in Open Babel's PQS parser caused an uninitialized pointer dereference when reading a crafted input file.
Details
The flaw was in the pFormat handling of the PQS reader. A malformed
input caused the parser to dereference a format pointer that had
never been initialized.
Impact
Open Babel is a C++ library and CLI used to read and write chemistry
file formats; it is shipped by Linux distributions and embedded in
services that may parse untrusted input. Triggering this vulnerability
requires the victim to open a malicious PQS file with the obabel
tool, the OBConversion API, or any of the language bindings (Python,
Ruby, Java, R, Perl, C#, PHP).
Affected versions
All releases up to and including 3.1.1.
Patched version
3.2.0 (released 2026-05-26).
Patch
Fix commit: https://github.com/openbabel/openbabel/commit/2a7d2cda
A minimized reproducer for this CVE is checked in under
test/files/fuzz_regress/ and is exercised on every CI build under
ASAN+UBSAN by the fuzzregresstest harness.
Credit
Reported by Cisco TALOS.
- Record
GHSA-8qxc-57hf-hc9j- CVSS 3.1
- 7.8 High
CVSS:3.1/AV:L/AC:L/PR:N/UI:R/S:U/C:H/I:H/A:H - Weakness
- CWE-824
- Updated
- 2026-11-02
NVD
9.8
A use of uninitialized pointer vulnerability exists in the PQS format pFormat functionality of Open Babel 3.1.1 and master commit 530dbfa3. A specially crafted malformed file can lead to arbitrary code execution. An attacker can provide a malicious file to trigger this vulnerability.
- Record
CVE-2022-46280- CVSS 3.1
- 9.8 Critical
CVSS:3.1/AV:N/AC:L/PR:N/UI:N/S:U/C:H/I:H/A:H - CVSS 3.1
- 7.8 High
CVSS:3.1/AV:L/AC:L/PR:N/UI:R/S:U/C:H/I:H/A:H - Weakness
- CWE-824
- Updated
- 2026-11-02
OSV
7.8
A use of uninitialized pointer vulnerability exists in the PQS format pFormat functionality of Open Babel 3.1.1 and master commit 530dbfa3. A specially crafted malformed file can lead to arbitrary code execution. An attacker can provide a malicious file to trigger this vulnerability.
- Record
CVE-2022-46280- CVSS 3.1
- 7.8 High
CVSS:3.1/AV:L/AC:L/PR:N/UI:R/S:U/C:H/I:H/A:H - Updated
- 2026-11-02
Show 7 moreShow less
OSVDEBIAN-CVE-2022-46280
7.8
A use of uninitialized pointer vulnerability exists in the PQS format pFormat functionality of Open Babel 3.1.1 and master commit 530dbfa3. A specially crafted malformed file can lead to arbitrary code execution. An attacker can provide a malicious file to trigger this vulnerability.
- Record
DEBIAN-CVE-2022-46280- CVSS 3.1
- 7.8 High
CVSS:3.1/AV:L/AC:L/PR:N/UI:R/S:U/C:H/I:H/A:H - Updated
- 2026-11-03
OSVGHSA-7rcm-w6ff-j43w
9.8
Duplicate Advisory: Open Babel has uninitialized pointer dereference in PQS pFormat
Duplicate Advisory
This advisory has been withdrawn because it is a duplicate of GHSA-8qxc-57hf-hc9j. This link is maintained to preserve external references.
Original Description
A use of uninitialized pointer vulnerability exists in the PQS format pFormat functionality of Open Babel 3.1.1 and master commit 530dbfa3. A specially crafted malformed file can lead to arbitrary code execution. An attacker can provide a malicious file to trigger this vulnerability.
- Record
GHSA-7rcm-w6ff-j43w- CVSS 3.1
- 9.8 Critical
CVSS:3.1/AV:N/AC:L/PR:N/UI:N/S:U/C:H/I:H/A:H - Weakness
- CWE-824
- Updated
- 2026-11-02
OSVGHSA-8qxc-57hf-hc9j
7.8
Open Babel has uninitialized pointer dereference in PQS pFormat
Summary
A memory-safety vulnerability in Open Babel's PQS parser caused an uninitialized pointer dereference when reading a crafted input file.
Details
The flaw was in the pFormat handling of the PQS reader. A malformed
input caused the parser to dereference a format pointer that had
never been initialized.
Impact
Open Babel is a C++ library and CLI used to read and write chemistry
file formats; it is shipped by Linux distributions and embedded in
services that may parse untrusted input. Triggering this vulnerability
requires the victim to open a malicious PQS file with the obabel
tool, the OBConversion API, or any of the language bindings (Python,
Ruby, Java, R, Perl, C#, PHP).
Affected versions
All releases up to and including 3.1.1.
Patched version
3.2.0 (released 2026-05-26).
Patch
Fix commit: https://github.com/openbabel/openbabel/commit/2a7d2cda
A minimized reproducer for this CVE is checked in under
test/files/fuzz_regress/ and is exercised on every CI build under
ASAN+UBSAN by the fuzzregresstest harness.
Credit
Reported by Cisco TALOS.
- Record
GHSA-8qxc-57hf-hc9j- CVSS 3.1
- 7.8 High
CVSS:3.1/AV:L/AC:L/PR:N/UI:R/S:U/C:H/I:H/A:H - Weakness
- CWE-824
- Updated
- 2026-11-02
OSVPYSEC-2026-2777
7.8
Open Babel has uninitialized pointer dereference in PQS pFormat
Summary
A memory-safety vulnerability in Open Babel's PQS parser caused an uninitialized pointer dereference when reading a crafted input file.
Details
The flaw was in the pFormat handling of the PQS reader. A malformed
input caused the parser to dereference a format pointer that had
never been initialized.
Impact
Open Babel is a C++ library and CLI used to read and write chemistry
file formats; it is shipped by Linux distributions and embedded in
services that may parse untrusted input. Triggering this vulnerability
requires the victim to open a malicious PQS file with the obabel
tool, the OBConversion API, or any of the language bindings (Python,
Ruby, Java, R, Perl, C#, PHP).
Affected versions
All releases up to and including 3.1.1.
Patched version
3.2.0 (released 2026-05-26).
Patch
Fix commit: https://github.com/openbabel/openbabel/commit/2a7d2cda
A minimized reproducer for this CVE is checked in under
test/files/fuzz_regress/ and is exercised on every CI build under
ASAN+UBSAN by the fuzzregresstest harness.
Credit
Reported by Cisco TALOS.
- Record
PYSEC-2026-2777- CVSS 3.1
- 7.8 High
CVSS:3.1/AV:L/AC:L/PR:N/UI:R/S:U/C:H/I:H/A:H - Updated
- 2026-11-02
OSVUBUNTU-CVE-2022-46280
9.8
A use of uninitialized pointer vulnerability exists in the PQS format pFormat functionality of Open Babel 3.1.1 and master commit 530dbfa3. A specially crafted malformed file can lead to arbitrary code execution. An attacker can provide a malicious file to trigger this vulnerability.
- Record
UBUNTU-CVE-2022-46280- CVSS 3.1
- 9.8 Critical
CVSS:3.1/AV:N/AC:L/PR:N/UI:N/S:U/C:H/I:H/A:H - CVSS 3.1
- 7.8 High
CVSS:3.1/AV:L/AC:L/PR:N/UI:R/S:U/C:H/I:H/A:H - Updated
- 2026-11-02
OSVopenSUSE-SU-2026:10936-1 No score
libopenbabel8-3.2.0-1.1 on GA media
These are all security issues fixed in the libopenbabel8-3.2.0-1.1 package on the GA media of openSUSE Tumbleweed.
- Record
openSUSE-SU-2026:10936-1- Updated
- 2026-11-02
OSVopenSUSE-SU-2026:21190-1 No score
Security update for openbabel
This update for openbabel fixes the following issues:
Changes in openbabel:
- Update to version 3.2.0:
- Add an L-BFGS optimizer, used by default for gen3d and conformer searches
- New macrocycle ring builder (Dale codes) for better initial 3D geometry of large rings
- Add KET (Ketcher JSON) and ChemicalJSON (.cjson) format support
- Drop Python 2 support; Python 3.13 supported
- Faster, vectorized distance-geometry implementation
- Full CMake 4 compatibility and modernized build
- Backwards compatible with 3.0 and 3.1
- Fix many crash and memory-safety bugs found via OSS-Fuzz and TALOS, including the following security issues: CVE-2022-37331 (boo#1217676), CVE-2022-41793, CVE-2022-42885, CVE-2022-43467, CVE-2022-43607, CVE-2022-44451, CVE-2022-46280, CVE-2022-46289, CVE-2022-46290, CVE-2022-46291, CVE-2022-46292, CVE-2022-46294, CVE-2022-46295, CVE-2025-10994, CVE-2025-10995, CVE-2025-10996, CVE-2025-10997, CVE-2025-10998, CVE-2025-10999, CVE-2025-11000, CVE-2026-2704 (boo#1258501), CVE-2026-2705 (boo#1258507) and CVE-2026-3408 (boo#1259041)
- Record
openSUSE-SU-2026:21190-1- Updated
- 2026-11-02
Affected products
Affected packages
| Package | Affected | Fixed |
|---|---|---|
openbabelPyPI |
before 3.2.0 | 3.2.0 |
openbabelDebian:12 |
All versions, plus listed versions 3.1.1+dfsg-103.1.1+dfsg-113.1.1+dfsg-123.1.1+dfsg-133.1.1+dfsg-14 Show 5 moreShow less3.1.1+dfsg-15~exp3.1.1+dfsg-93.2.0+dfsg-13.2.0+dfsg-1~exp3.2.0+dfsg-2 |
None known |
openbabelDebian:13 |
All versions, plus listed versions 3.1.1+dfsg-123.1.1+dfsg-133.1.1+dfsg-143.1.1+dfsg-15~exp3.2.0+dfsg-13.2.0+dfsg-1~exp3.2.0+dfsg-2 |
None known |
openbabelDebian:14 |
All versions, plus listed versions 3.1.1+dfsg-123.1.1+dfsg-133.1.1+dfsg-143.1.1+dfsg-15~exp3.2.0+dfsg-13.2.0+dfsg-1~exp3.2.0+dfsg-2 |
None known |
openbabelPyPI |
before 3.2.0, plus listed versions 1.81.8.11.8.21.8.31.8.4 Show 6 moreShow less2.4.02.4.13.0.03.0.0a13.1.13.1.1.1 |
3.2.0 |
openbabelUbuntu:16.04:LTS |
All versions, plus listed versions 2.3.2+dfsg-2.22.3.2+dfsg-2.2build1 |
None known |
openbabelUbuntu:18.04:LTS |
All versions, plus listed versions 2.3.2+dfsg-3build1 |
None known |
openbabelUbuntu:20.04:LTS |
All versions, plus listed versions 2.4.1+dfsg-32.4.1+dfsg-3build12.4.1+dfsg-5.12.4.1+dfsg-63.0.0+dfsg-33.0.0+dfsg-3ubuntu3 |
None known |
openbabelUbuntu:22.04:LTS |
All versions, plus listed versions 3.1.1+dfsg-6ubuntu13.1.1+dfsg-6ubuntu5 |
None known |
openbabelUbuntu:24.04:LTS |
All versions, plus listed versions 3.1.1+dfsg-9build23.1.1+dfsg-9ubuntu13.1.1+dfsg-9ubuntu23.1.1+dfsg-9ubuntu43.1.1+dfsg-9ubuntu5 |
None known |
Show 5 moreShow less
| Package | Affected | Fixed |
|---|---|---|
openbabelUbuntu:25.10 |
All versions, plus listed versions 3.1.1+dfsg-11ubuntu33.1.1+dfsg-11ubuntu4 |
None known |
openbabelUbuntu:26.10 |
All versions, plus listed versions 3.1.1+dfsg-11ubuntu53.1.1+dfsg-14ubuntu2 |
None known |
openbabelUbuntu:26.04:LTS |
All versions, plus listed versions 3.1.1+dfsg-11ubuntu43.1.1+dfsg-11ubuntu5 |
None known |
openbabelopenSUSE:Tumbleweed From an advisory covering 8 CVEs |
before 3.2.0-1.1 | 3.2.0-1.1 |
openbabelopenSUSE:Leap 16.0 From an advisory covering 23 CVEs |
before 3.2.0-bp160.1.1 | 3.2.0-bp160.1.1 |
History
| Recorded | Changed | Sources |
|---|---|---|
| affected, facts | OSV | |
| affected | OSV | |
| affected | ||
| first indexed | CVE List, EUVD, GitHub Advisories, NVD, OSV |
Dates are when Every CVE recorded each change. Upstream dates may differ.
In short
CVE-2022-46280 is a critical vulnerability (CVSS 9.8) in Open Babel Babel, published July 21, 2023. No source lists public exploit code. EPSS puts the chance of exploitation in the next 30 days at 0.83%, the 57th percentile. Fixed in openbabel 3.2.0.
References
talosintelligence.com/vulnerability_reports/TALOS-2022-1670
github.com/openbabel/openbabel/security/advisories/GHSA-8qxc-57hf-hc9j
nvd.nist.gov/vuln/detail/CVE-2022-46280
github.com/openbabel/openbabel/commit/2a7d2cda8bd47daade2e555e34b69651a2e132ef
github.com/advisories/GHSA-7rcm-w6ff-j43w
github.com/advisories/GHSA-8qxc-57hf-hc9j
Show 32 moreShow less
security-tracker.debian.org/tracker/CVE-2022-46280
github.com/openbabel/openbabel
pypi.org/project/openbabel
ubuntu.com/security/CVE-2022-46280
cve.org/CVERecord?id=CVE-2022-46280
suse.com/security/cve/CVE-2022-37331
suse.com/security/cve/CVE-2022-43467
suse.com/security/cve/CVE-2022-46280
suse.com/security/cve/CVE-2022-46291
suse.com/security/cve/CVE-2022-46295
suse.com/security/cve/CVE-2025-10996
suse.com/security/cve/CVE-2025-10999
suse.com/security/cve/CVE-2026-2705
bugzilla.suse.com/1217676
bugzilla.suse.com/1258501
bugzilla.suse.com/1258507
bugzilla.suse.com/1259041
suse.com/security/cve/CVE-2022-41793
suse.com/security/cve/CVE-2022-42885
suse.com/security/cve/CVE-2022-43607
suse.com/security/cve/CVE-2022-44451
suse.com/security/cve/CVE-2022-46289
suse.com/security/cve/CVE-2022-46290
suse.com/security/cve/CVE-2022-46292
suse.com/security/cve/CVE-2022-46294
suse.com/security/cve/CVE-2025-10994
suse.com/security/cve/CVE-2025-10995
suse.com/security/cve/CVE-2025-10997
suse.com/security/cve/CVE-2025-10998
suse.com/security/cve/CVE-2025-11000
suse.com/security/cve/CVE-2026-2704
suse.com/security/cve/CVE-2026-3408