CVE-2024-50636
PyMOL 2.5.0 contains a vulnerability in its "Run Script" function, which allows the execution of...
PyMOL 2.5.0 contains a vulnerability in its "Run Script" function, which allows the execution of arbitrary Python code embedded within .PYM files. Attackers can craft a malicious .PYM file containing a Python reverse shell payload and exploit the function to achieve Remote Command Execution (RCE). This vulnerability arises because PyMOL treats .PYM files as Python scripts without properly validating or restricting the commands within the script, enabling attackers to run unauthorized commands in the context of the user running the application.
Attack profile
How easy it is to exploit
- Attack vector
- Network
- Complexity
- Low
- Privileges needed
- None
- User interaction
- None
What an attacker can affect
- Confidentiality
- High
- Integrity
- High
- Availability
- High
Exploit likelihood
What each source reports
CVE List Score used
PyMOL 2.5.0 contains a vulnerability in its "Run Script" function, which allows the execution of arbitrary Python code embedded within .PYM files. Attackers can craft a malicious .PYM file containing a Python reverse shell payload and exploit the function to achieve Remote Command Execution (RCE). This vulnerability arises because PyMOL treats .PYM files as Python scripts without properly validating or restricting the commands within the script, enabling attackers to run unauthorized commands in the context of the user running the application.
- Record
CVE-2024-50636- CVSS 3.1
- 9.8 Critical
CVSS:3.1/AV:N/AC:L/PR:N/UI:N/S:U/C:H/I:H/A:H - Weakness
- CWE-94
- Updated
- 2026-11-02
EUVDEUVD-2024-44948
PyMOL 2.5.0 contains a vulnerability in its "Run Script" function, which allows the execution of arbitrary Python code embedded within .PYM files. Attackers can craft a malicious .PYM file containing a Python reverse shell payload and exploit the function to achieve Remote Command Execution (RCE). This vulnerability arises because PyMOL treats .PYM files as Python scripts without properly validating or restricting the commands within the script, enabling attackers to run unauthorized commands in the context of the user running the application.
- Record
EUVD-2024-44948- CVSS 3.1
- 9.8 Critical
CVSS:3.1/AV:N/AC:L/PR:N/UI:N/S:U/C:H/I:H/A:H - Updated
- 2026-11-03
GitHub AdvisoriesGHSA-wq8w-m2g8-mv57
PyMOL 2.5.0 contains a vulnerability in its "Run Script" function, which allows the execution of...
PyMOL 2.5.0 contains a vulnerability in its "Run Script" function, which allows the execution of arbitrary Python code embedded within .PYM files. Attackers can craft a malicious .PYM file containing a Python reverse shell payload and exploit the function to achieve Remote Command Execution (RCE). This vulnerability arises because PyMOL treats .PYM files as Python scripts without properly validating or restricting the commands within the script, enabling attackers to run unauthorized commands in the context of the user running the application.
- Record
GHSA-wq8w-m2g8-mv57- CVSS 3.1
- 9.8 Critical
CVSS:3.1/AV:N/AC:L/PR:N/UI:N/S:U/C:H/I:H/A:H - Weakness
- CWE-94
- Updated
- 2026-11-02
NVD
PyMOL 2.5.0 contains a vulnerability in its "Run Script" function, which allows the execution of arbitrary Python code embedded within .PYM files. Attackers can craft a malicious .PYM file containing a Python reverse shell payload and exploit the function to achieve Remote Command Execution (RCE). This vulnerability arises because PyMOL treats .PYM files as Python scripts without properly validating or restricting the commands within the script, enabling attackers to run unauthorized commands in the context of the user running the application.
- Record
CVE-2024-50636- CVSS 3.1
- 9.8 Critical
CVSS:3.1/AV:N/AC:L/PR:N/UI:N/S:U/C:H/I:H/A:H - Weakness
- CWE-94
- Updated
- 2026-11-02
OSVUBUNTU-CVE-2024-50636
PyMOL 2.5.0 contains a vulnerability in its "Run Script" function, which allows the execution of arbitrary Python code embedded within .PYM files. Attackers can craft a malicious .PYM file containing a Python reverse shell payload and exploit the function to achieve Remote Command Execution (RCE). This vulnerability arises because PyMOL treats .PYM files as Python scripts without properly validating or restricting the commands within the script, enabling attackers to run unauthorized commands in the context of the user running the application.
- Record
UBUNTU-CVE-2024-50636- CVSS 3.1
- 9.8 Critical
CVSS:3.1/AV:N/AC:L/PR:N/UI:N/S:U/C:H/I:H/A:H - Updated
- 2026-11-02
Affected products
Affected packages
| Package | Affected | Fixed |
|---|---|---|
pymolUbuntu:16.04:LTS |
All versions, plus listed versions 1.7.2.1-21.7.2.1-2.11.7.2.1-2.1build11.7.2.1-2.2 |
None known |
pymolUbuntu:18.04:LTS |
All versions, plus listed versions 1.8.4.0+dfsg-1build1 |
None known |
pymolUbuntu:20.04:LTS |
All versions, plus listed versions 2.2.0+dfsg-42.2.0+dfsg-4build12.3.0+dfsg-12.3.0+dfsg-1build1 |
None known |
pymolUbuntu:22.04:LTS |
All versions, plus listed versions 2.4.0+dfsg-32.4.0+dfsg-3build22.5.0+dfsg-12.5.0+dfsg-1build1 |
None known |
pymolUbuntu:24.04:LTS |
All versions, plus listed versions 2.5.0+dfsg-1build32.5.0+dfsg-1build42.5.0+dfsg-1build52.5.0+dfsg-1build6 |
None known |
pymolUbuntu:25.10 |
All versions, plus listed versions 3.1.0+dfsg-13.1.0+dfsg-1build1 |
None known |
pymolUbuntu:26.10 |
All versions, plus listed versions 3.1.0+dfsg-1build33.1.0+dfsg-1build4 |
None known |
pymolUbuntu:26.04:LTS |
All versions, plus listed versions 3.1.0+dfsg-1build13.1.0+dfsg-1build23.1.0+dfsg-1build3 |
None known |
History
| Recorded | Changed | Sources |
|---|---|---|
| aliases | EUVD | |
| first indexed | CVE List, GitHub Advisories, NVD, OSV |
Dates are when Every CVE recorded each change. Upstream dates may differ.
In short
CVE-2024-50636 is a critical vulnerability (CVSS 9.8) in Schrodinger Pymol, published November 11, 2024. No source lists public exploit code. EPSS puts the chance of exploitation in the next 30 days at 1.25%, the 69th percentile. No source names a fixed version.